Cut a smaller hole above the destination of each wire close to where the receiver will be positioned. If you are going across ceiling joists, cut smaller notches below each joist so the wire can jump in and out of the ceiling. Fish tape wouldn't be needed in this circumstance, but these holes will later need to be patched up with spackle.
In longer ceiling bays, feed the fish tape through the hole from starting point to destination.
Pop the grill on the front of the speaker.
Mark and feed the positive and negative feeds, and attach the speakers to the ceiling for any other speakers.
Feed the opposite ends of the speaker wire into the positive and negative feeds in the receiver or a speaker selector, if applicable. If you are running the wiring to a speaker selector, you will need additional speaker wire to run the feed from the speaker selector to the receiver.