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Set the drill on a low speed. Use a 3/8" drill bit to drill holes in the bottom of the aspirin bottle. After drilling, clean out the plastic shavings.
Fit one end of a 3/8" piece of flexible tubing into one hole. Fit the end of the other 3/8" piece of tubing into the second hole.
To make sure the tubing is air-tight inside the bottle, apply silicone caulk around the margins of the holes in the aspirin bottle.